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Hepatitis C
Published by BUPA's health information team, healthinfo@bupa.com, December 2006.
This factsheet is for people who have been diagnosed with hepatitis C (hep C) and those who want to know more about the virus.
Hepatitis means inflammation of the liver and can have several causes, the most common of which is an infection with a hepatitis virus. There are a number of different hepatitis viruses, including hepatitis C, and each differs in the way it's passed from person to person and the effect it can have on health. Hepatitis C is sometimes called hep C or HCV. For information about hepatitis, A or B please see the separate BUPA factsheets, Hepatitis A and Hepatitis B.
Causes of hepatitis C
Hepatitis can have several causes including:
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infection, usually from a virus
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excessive alcohol intake or other toxins/chemicals
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auto-immune disorders where the liver is attacked by the body's own immune system
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metabolic diseases (caused by a chemical imbalance in the body)
Of these, infection with a virus is the most common cause.
About hepatitis C
There are different strains of hepatitis C. Different strains are more common in different countries. The most common in the UK and Europe are genotypes 1,2,3. There are also subtypes which are labelled a, b and c.
How do you get hepatitis C?
Someone infected with hepatitis C has the virus in their blood. If blood from an infected person gets into your bloodstream you can get hepatitis C. There are a number of ways this could happen including:
- using contaminated needles to inject drugs - this is the most common way hepatitis C is spread and the virus can sometimes be spread through shared use of other equipment such as syringes
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through an open wound
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from contaminated medical or dental equipment which is not sterilised properly
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from contaminated equipment used in tattooing which is not sterilised properly
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from blood donations in countries where blood is not tested (in the UK all blood donations are now tested for hepatitis C)
Sex
If you have unprotected sex with an infected person you may get hepatitis C, although this is rare. It is not known whether the infection that occurs is due to a couple having sex or for other reasons such as sharing a contaminated personal item such as a toothbrush or razor where blood transmission occurs. People with new or casual sexual partners should practice safe sex and use condoms.
From mother to baby
It is possible for the hepatitis C virus to be passed on during childbirth but this is also rare. In the UK, the virus is spread from a mother with hepatitis C to her baby 6 times in 100 births.
There is no evidence to suggest that a mother can pass the virus to her baby through breastfeeding.
Where is hepatitis C common?
The exact number of people infected is not known but it is estimated that about 1 in 1000 people have hepatitis C in the UK and about 170 million people worldwide carry the virus.
Most cases are in people who have injected illegal drugs using contaminated needles.
Symptoms of hepatitis C
Hepatitis C has an incubation period of about 7-8 weeks. This is the time from exposure to the virus to the start of symptoms. Many people never have any symptoms of hepatitis. They are known as asymptomatic carriers; they are still infectious and can unknowingly pass on the disease to others.
Symptoms of hepatitis, when there are any, can be similar to flu. They can include:
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extreme tiredness
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nausea and vomiting
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loss of appetite
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headache
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fever
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aching limbs
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alcohol intolerance
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pain in the right side of the abdomen
Jaundice sometimes develops and makes your skin go yellow. This is caused by a yellow-coloured substance in the blood called bilirubin. It's usually broken down by the liver, but if your liver is affected by hepatitis, it's unable to break it down. Raised bilirubin levels in your blood cause the whites of your eyes to go yellow and your urine to become dark. Jaundice can also cause your skin to itch.
Most people only develop mild hepatitis symptoms and it is unusual for symptoms to be severe. This means that you may not notice that you are infected.
Complications of hepatitis C
About 5-30 percent of people who are infected develop cirrhosis (scarring of the liver) over a period of 20-30 years. This can lead to liver failure (called fulminant hepatitis). Some people may become so seriously ill that they need a liver transplant.
Acute and chronic hepatitis C
Hepatitis C can be "acute" or "chronic".
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An acute illness is typically over quite quickly - within weeks or months.
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A chronic illness is one that lasts more than six months, sometimes for the rest of the affected person's life.
About 80 percent of people infected go on to develop chronic hepatitis C.
A person who has the virus in their body for a long time without experiencing symptoms is called a carrier. Most carriers are infectious but some get rid of the virus after a few years.
Diagnosis of hepatitis C
Your doctor will examine you and ask you about your symptoms. He or she may ask you for a blood sample. The sample will be sent to a laboratory for examination to find out if you are infected with the hepatitis C virus. Rather than show whether the virus is present, the sample will show if your body is producing antibodies against it. The test may therefore need to be repeated as it may take a long time (weeks or even months) for your body to start producing antibodies.
If tests results show that you have hepatitis C you may have further tests including:
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a "liver function" blood test to measure substances in the blood that indicate whether the liver is damaged
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a biopsy, in which a small tissue sample is removed, which is examined in a laboratory to find out if your liver is damaged
Treatment of hepatitis C
Most people with acute hepatitis C do not need any treatment. If you are diagnosed with hepatitis C, your GP will generally advise you to rest as you may feel more tired than usual.
Taking a painkiller that you would normally take for a headache, such as aspirin or ibuprofen, may be useful. Always read the patient information leaflet. You should not take paracetamol as it is processed by the liver. As your liver will not be working properly, it is also strongly advisable to not drink any alcohol.
If you have jaundice and your skin is itchy you can try preparations such as calamine lotion or crotamiton (Eurax).
If you have been infected with chronic hepatitis C you may find treatment helpful.
Antiviral medication
Hepatitis C treatment can include the use of antiviral treatments. These are usually prescribed by a specialist nurse or consultant that your GP will refer you to. The antiviral drugs include the following.
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Peginterferon alpha (eg Pegasys) in combination with ribavirin (eg Copegus) is a treatment for adults with chronic hepatitis C. Peginterferon alpha is given by injection and ribavirin is given by tablet. You cannot take ribavirin if you are pregnant.
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Peginterferon alpha alone is an alternative treatment if ribavirin is not suitable for you - ribavirin alone is not effective.
These drugs are not suitable for everyone, your consultant or specialist nurse will give you advice about whether they are the best treatment for you.
How can I avoid passing on the virus?
If you are infected with hepatitis C it is important not to spread it to others. You should:
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not donate blood
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not share any needles, syringes, razors or toothbrushes that may be contaminated with blood
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cover cuts with a dressing
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not have unprotected sex
Prevention of hepatitis C
You can prevent getting hepatitis C by avoiding the risk factors above.
There is currently no vaccine available to prevent people that are at risk from becoming infected with the hepatitis C virus.
Further information
Sources
- Hepatitis C - general information. Health Protection Agency (HPA). www.hpa.org.uk, accessed 1 June 2006
- Hepatitis C. World Health Organisation. www.who.int, accessed 31 May 2006
- Hepatitis C. Fighting Liver Disease. British Liver Trust. www.britishlivertrust.org.uk, accessed 31 May 2006
- Peginterferon alfa and ribavirin for the treatment of mild chronic hepatitis C. National Institute of Clinical Excellence (NICE), May 2006, final appraisal determination. www.nice.org.uk
- Hepatitis C. UK Department of Health. PRODIGY. www.prodigy.nhs.uk, accessed 30 June 2006
- Eddleston M, Pierini S. Oxford Handbook of Tropical Medicine. Oxford: Oxford University Press, 1999:370
- Simon C, Everitt H, Birtwistle J, Stevenson B. Oxford Handbook of General Practice. Oxford: Oxford University Press, 2002:466-467
- BNF British National Formulary 50, September 2005
Related topics
This information was published by BUPA's health information team and is based on reputable sources of medical evidence and has been reviewed by BUPA doctors. The content is intended for general information only and does not replace the need for personal advice from a qualified health professional.
Publication date: December 2006. Expected review date: December 2008.
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